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In The Witcher, keys are almost exclusively, but not entirely Αντικείμενα αποστολών. As such, they are placed in Γκέραλτ's quest item inventory pocket and they stay there, safely. They can not be lost which is very handy. There are quite a few keys in the game and many of them look alike, hopefully the list below will help make sense of them.
Keys are neither required nor found in the Prologue.
Keys are neither required nor found in Κεφάλαιοs IV and V.
Old key to cellar door, found in trunk in first cellar (of the safe house) with Vetala.
Old key to sewers (zeugl's lair), received from a wounded knight of the Order, or Triss.
Ornamented key to the Grand Master's chambers. Taken from corpse(s) of Knights guarding the entrance.
Non-quest Item keys
Key to Ramsmeat's place in the Συνοικία του Ναού slums, which you can acquire by killing his guards at night (apparently, he is not bothered by this in the least). This is the only key in the game which does not go into the quest items inventory pocket, and so, could actually be lost or accidentally dropped. Of course, depending on how you make your choices in this game, you may never need this key, and you can just pay the guards, but that is each time you go.